4′-thio-RNA:: Synthesis, base pairing properties and interaction with dimerization initiation site of HIV-1

被引：6

作者：

Dukhan, D

De Valette, F

Marquet, R

Ehresmann, B

Ehresmann, C

Morvan, F

Barascut, JL

Imbach, JL

机构：

[1] Chim Bioorgan Lab, F-34095 Montpellier, France

[2] Inst Biol Mol & Cellulaire, F-67084 Strasbourg, France

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 6-7期

关键词：

D O I：

10.1080/07328319908044740

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present paper, we describe the synthesis of a modified 9-mer oligonucleotide, 4'-S-r(UGUGCACCU) containing for the first time 4'-thio-guanosine units. This modified 9-mer was found to inhibit in vitro genomic RNA dimerization as well as the wild type RNA.

引用

页码：1423 / 1424

页数：2

共 2 条

[1] 4'-THIO-RNA - SYNTHESIS OF MIXED BASE 4'-THIO-OLIGORIBONUCLEOTIDES, NUCLEASE RESISTANCE, AND BASE-PAIRING PROPERTIES WITH COMPLEMENTARY SINGLE AND DOUBLE-STRAND [J].