A case of aconitine poisoning with analysis of aconitine alkaloids by GC/SIM

被引：44

作者：

Yoshioka, N

Gonmori, K

Tagashira, A

Boonhooi, O

Hayashi, M

Saito, Y

Mizugaki, M

机构：

[1] HIRAKA GEN HOSP,YOKOTE 013,JAPAN

[2] UGO CITY HOSP,UGO 01211,JAPAN

[3] TOHOKU UNIV HOSP,DEPT PHARMACEUT SCI,AOBA KU,SENDAI,MIYAGI 98077,JAPAN

来源：

FORENSIC SCIENCE INTERNATIONAL | 1996年 / 81卷 / 2-3期

关键词：

aconitine; aconitine alkaloids; poisoning; arrhythmia; GC/selected ion monitoring (GC/SIM);

D O I：

10.1016/S0379-0738(96)01980-9

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Described here is a fatal case of accidental aconitine poisoning following the ingestion of aconite, Torikabuto, mistaken for an edible grass, Momijigasa. A 61-year-old man developed symptoms of nausea, diarrhea, and discomfort of the body about 2 h after the ingestion and was taken to an emergency room. Resuscitation and antiarrhythmic drugs were ineffective, and ventricular tachycardia and fibrillation developed and lasted for 6 h. He was transferred to a coronary care unit and complete sinus rhythm was obtained on an electrocardiogram 30 h after his admission. The patient fell into a coma and died of brain edema diagnosed by CT on the 6th day, Consent for autopsy was denied by the family but was given for gas chromatography/selected ion monitoring (GC/SIM) to analyze the toxicity of aconitine alkaloids in the blood and the urine, Only a faint amount of jesaconitine was detected, while aconitine, mesaconitine and hypaconitine were not detectable in the blood 24 h after ingestion. On the other hand, aconitine and its related alkaloids such as mesaconitine, jesaconitine, and hypaconitine were clearly detected in the urine.

引用

页码：117 / 123

页数：7

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