A potential novel strategy to separate therapeutic- and side-effects that are mediated via the same receptor:: β-arresting2/G-protein coupling antagonists

被引:11
作者
Bruns, I. R. [1 ]
Chhum, S. [1 ]
Dinh, A. T. [1 ]
Doerr, H. [1 ]
Dunn, N. R. [1 ]
Ly, Y. T. [1 ]
Mitman, C. L. [1 ]
Rickards, H. D. [1 ]
Sol, C. [1 ]
Wan, E. W. [1 ]
Raffa, R. B. [1 ]
机构
[1] Temple Univ, Sch Pharm, Philadelphia, PA 19140 USA
关键词
D O I
10.1111/j.1365-2710.2006.00714.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:119 / 128
页数:10
相关论文
共 61 条
[1]  
AHNS S, 2003, P NATL ACAD SCI US A, V100, P1740
[2]   Structure-activity relationships for the design of small-molecule inhibitors [J].
Andricopulo, AD ;
Montanari, CA .
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2005, 5 (06) :585-593
[3]  
ARDEN JR, 1995, J NEUROCHEM, V65, P1636
[4]  
ATTRAMADAL H, 1992, J BIOL CHEM, V267, P17882
[5]  
BIRNBAUMER L, 1990, ANNU REV PHARMACOL, V30, P675
[6]   μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence [J].
Bohn, LM ;
Gainetdinov, RR ;
Lin, FT ;
Lefkowitz, RJ ;
Caron, MG .
NATURE, 2000, 408 (6813) :720-723
[7]   Enhanced morphine analgesia in mice lacking β-arrestin 2 [J].
Bohn, LM ;
Lefkowitz, RJ ;
Gainetdinov, RR ;
Peppel, K ;
Caron, MG ;
Lin, FT .
SCIENCE, 1999, 286 (5449) :2495-2498
[8]   Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery [J].
Bohn, LM ;
Dykstra, LA ;
Lefkowitz, RJ ;
Caron, MG ;
Barak, LS .
MOLECULAR PHARMACOLOGY, 2004, 66 (01) :106-112
[9]   G protein-coupled receptor kinase/β-arrestin systems and drugs of abuse -: Psychostimulant and opiate studies in knockout mice [J].
Bohn, LM ;
Gainetdinov, RR ;
Caron, MG .
NEUROMOLECULAR MEDICINE, 2004, 5 (01) :41-50
[10]  
Bohn LM, 2003, J NEUROSCI, V23, P10265