Lymphotoxin network pathways shape the tumor microenvironment

被引：31

作者：

Bjordahl, Ryan L. ^{[1
]}

Steidl, Christian ^{[2
,3
]}

Gascoyne, Randy D. ^{[2
,3
]}

Ware, Carl F. ^{[1
]}

机构：

[1] Sanford Burnham Med Res Inst, Infect & Inflammatory Dis Ctr, La Jolla, CA 92037 USA

[2] Univ British Columbia, Dept Pathol, Vancouver, BC V5Z 1M9, Canada

[3] British Columbia Canc Res Ctr, Ctr Lymphoid Canc, Dept Expt Therapeut, Vancouver, BC V5Z 1L3, Canada

来源：

CURRENT OPINION IN IMMUNOLOGY | 2013年 / 25卷 / 02期

基金：

美国国家卫生研究院;

关键词：

T-LYMPHOCYTE ATTENUATOR; ENTRY MEDIATOR TNFRSF14; FOLLICULAR LYMPHOMA; RHEUMATOID-ARTHRITIS; TNF RECEPTOR; CELLS; SURVIVAL; BTLA; ASSOCIATION; EXPRESSION;

D O I：

10.1016/j.coi.2013.01.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Accumulating evidence indicates that Lymphotoxin (LY)-beta related cytokines directly contribute to the phenotype of cancer cells and alter the tumor microenvironment. Lymphotoxins are part of a cytokine network well known in controlling the development and homeostasis of secondary lymphoid organs. In the adult, the LT network takes on the responsibility of generating inflammatory microenvironments that control innate and adaptive immune responses involved in host defense. This review provides a perspective of the emerging evidence implicating the LT Network in the development and progression of various cancers including lymphoma. Redirecting the LT Network to alter tumor microenvironments may provide a specific approach to therapeutically target tumor-permissive microenvironments and cancer progression.

引用

页码：222 / 229

页数：8

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