In vivo quantification of citrate concentration and water T-2 relaxation time of the pathologic prostate gland using H-1 MRS and MRI

被引：70

作者：

Liney, GP ^{[1
]}

Turnbull, LW ^{[1
]}

Lowry, M ^{[1
]}

Turnbull, LS ^{[1
]}

Knowles, AJ ^{[1
]}

Horsman, A ^{[1
]}

机构：

[1] UNIV HULL, DEPT MED PHYS, KINGSTON UPON HULL HU6 7RX, N HUMBERSIDE, ENGLAND

来源：

MAGNETIC RESONANCE IMAGING | 1997年 / 15卷 / 10期

关键词：

magnetic resonance imaging; magnetic resonance spectroscopy; prostate cancer; benign prostatic hyperplasia;

D O I：

10.1016/S0730-725X(97)00182-3

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We have previously reported a striking correlation between water T-2 relaxation time and citrate concentration in the normal prostate (Liney G.P.; Lowry M.; Turnbull L.W.; Manton D.J.; Knowles A.J.; Blackband S.J.; Horsman A. Proton MR T-2 maps correlate with the citrate concentration in the prostate. NMR Biomed. 9:59-64; 1996). In this study we present data from similar studies of the pathologic gland. The findings support the hypothesis that measurement of both citrate concentration and water T-2 relaxation time in vivo may aid the differentiation of prostatic carcinoma from benign disease and normal tissue. (C) 1997 Elsevier Science Inc.

引用

页码：1177 / 1186

页数：10

共 27 条

[1] QUANTITATION OF PROTON NMR-SPECTRA OF THE HUMAN BRAIN USING TISSUE WATER AS AN INTERNAL CONCENTRATION REFERENCE [J].

BARKER, PB ;

SOHER, BJ ;

BLACKBAND, SJ ;

CHATHAM, JC ;

MATHEWS, VP ;

BRYAN, RN .

NMR IN BIOMEDICINE, 1993, 6 (01) :89-94

[2] PROSTATIC-CARCINOMA - STAGING WITH MR IMAGING AT 1.5-T [J].

BEZZI, M ;

KRESSEL, HY ;

ALLEN, KS ;

SCHIEBLER, ML ;

ALTMAN, HG ;

WEIN, AJ ;

POLLACK, HM .

RADIOLOGY, 1988, 169 (02) :339-346

[3] CLINICAL STAGE-B PROSTATE CARCINOMA - STAGING WITH MR IMAGING [J].

BIONDETTI, PR ;

LEE, JKT ;

LING, D ;

CATALONA, WJ .

RADIOLOGY, 1987, 162 (02) :325-329

[4] CANCER STATISTICS, 1994 [J].

BORING, CC ;

SQUIRES, TS ;

TONG, T ;

MONTGOMERY, S .

CA-A CANCER JOURNAL FOR CLINICIANS, 1994, 44 (01) :7-26

[5] ROLE OF CITRIC ACID IN PHYSIOLOGY OF PROSTATE .3. LACTATE/CITRATE RATIOS IN BENIGN + MALIGNANT PROSTATIC HOMOGENATES AS INDEX OF PROSTATIC MALIGNANCY [J].

COOPER, JF ;

FARID, I .

JOURNAL OF UROLOGY, 1964, 92 (05) :533-&

[6] CHARACTERIZATION OF HUMAN PROSTATE-CANCER, BENIGN PROSTATIC HYPERPLASIA AND NORMAL PROSTATE BY IN-VITRO H-1 AND P-31 MAGNETIC-RESONANCE SPECTROSCOPY [J].

CORNEL, EB ;

SMITS, GAHJ ;

OOSTERHOF, GON ;

KARTHAUS, HFM ;

DEBRUYNE, FMJ ;

SCHALKEN, JA ;

HEERSCHAP, A .

JOURNAL OF UROLOGY, 1993, 150 (06) :2019-2024

[7] PROSTATE EPITHELIAL-CELLS UTILIZE GLUCOSE AND ASPARTATE AS THE CARBON-SOURCES FOR NET CITRATE PRODUCTION [J].

COSTELLO, LC ;

FRANKLIN, RB .

PROSTATE, 1989, 15 (04) :335-342

[8] CONCEPTS OF CITRATE PRODUCTION AND SECRETION BY PROSTATE .1. METABOLIC RELATIONSHIPS [J].

COSTELLO, LC ;

FRANKLIN, RB .

PROSTATE, 1991, 18 (01) :25-46

[9]

COSTELLO LC, 1978, ENDOCRINE CONTROL NE, P303

[10]

HEERSCHAP A, 1993, SOC MAGNETIC RESONAN, V1, P213

← 1 2 3 →