Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice

被引：85

作者：

Ciurea, A ^{[1
]}

Klenerman, P ^{[1
]}

Hunziker, L ^{[1
]}

Horvath, E ^{[1
]}

Odermatt, B ^{[1
]}

Ochsenbein, AF ^{[1
]}

Hengartner, H ^{[1
]}

Zinkernagel, RM ^{[1
]}

机构：

[1] Univ Zurich Hosp, Inst Expt Immunol, Dept Pathol, CH-8091 Zurich, Switzerland

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1999年 / 96卷 / 21期

基金：

英国惠康基金;

关键词：

D O I：

10.1073/pnas.96.21.11964

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lymphocytic choriomeningitis virus (LCMV), strain WE, is a noncytopathic RNA virus that is highly adapted to its natural host, the mouse. Acute infection of adult mice leads to generalized virus spread, followed by cytotoxic T lymphocyte-mediated virus clearance below the detection levels of conventional assays within 2-3 weeks. Indirect evidence had suggested that virus or viral antigen might persist in the immune mouse. Here we demonstrate LCMV-WE persistence at low levels after infection with 10(2) or 10(6) plaque-forming units, shown as Viral genome, viral antigen, and replicative virus using sensitive in vitro and in vivo assays. The finding that LCMV-WE persists in the face of apparently intact immune responses resembles the situation in some viral (hepatitis B and C, HIV) and bacterial (tuberculosis, leprosy) infections in humans; the results are relevant to the understanding not only of other murine and human persistent viral infections but also of protective immunological memory by "infection immunity."

引用

页码：11964 / 11969

页数：6

共 42 条

[1] IMMUNE THERAPY OF A PERSISTENT AND DISSEMINATED VIRAL-INFECTION [J].