Spatial learning deficits and emotional impairments in pentylenetetrazole-kindled rats

被引:137
作者
Mortazavi, F
Ericson, M
Story, D
Hulce, VD
Dunbar, GL [1 ]
机构
[1] Cent Michigan Univ, Dept Psychol, Brain Res & Integrat Neurosci Ctr, Mt Pleasant, MI 48859 USA
[2] Field Neurosci Inst, Saginaw, MI 48604 USA
关键词
pentylenetetrazole; kindling; spatial learning; radial arm water maze; behavior; epilepsy; fear; depression; aggression; open field;
D O I
10.1016/j.yebeh.2005.08.019
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 [法学]; 0303 [社会学]; 030303 [人类学]; 04 [教育学]; 0402 [心理学];
摘要
Pentylenetetrazole (PTZ) is a chemical kindling agent Used to examine the efficacy of potential anticonvulsants ill rats. However, the extent to which PTZ mimics postseizure symptoms of epilepsy has not been thoroughly examined. This study assessed whether PTZ-induced seizures produce cognitive and emotional deficits that mimic those observed in many epileptic patients. Rats were given 30 mg/kg PTZ or vehicle (intraperitoneally) every other day for 28 days. Those rats exhibiting consistent seizure activity were tested for learning ability and emotional reactivity, beginning I week following a single challenge dose of PTZ. Rats given PTZ made more reference memory errors in a radial arm water maze task, and exhibited emotional abnormalities in the forced swim test, the systematic handling test, and the open-field exploratory maze. Histological analysis revealed neuronal loss in the CA1 area and increased mossy fiber sprouting ill the dentate gyrus, similar to what is observed in human epilepsy. These results indicate that PTZ kindling provides a useful model of postseizure dysfunction, which can serve as a screen for potential treatments for those cognitive, emotional, and neuropathological deficits that resemble those symptoms observed in human epilepsy. (C) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:629 / 638
页数:10
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