A convenient way to synthesize comb-shaped chitosan-graft-poly (N-isopropylacrylamide) copolymer

被引：44

作者：

Chen, Chen ^{[1
,2
]}

Liu, Mingzhu ^{[1
,2
]}

Gao, Chunmei ^{[1
,2
]}

Lu, Shaoyu ^{[1
,2
]}

Chen, Jiucun ^{[1
,2
]}

Yu, Xiyong ^{[3
]}

Ding, Enyong ^{[4
]}

Yu, Chuanming ^{[1
,2
]}

Guo, Jing ^{[1
,2
]}

Cui, Guijia ^{[1
,2
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China

[3] Guangdong Gen Hosp, Med Res Ctr, Guangzhou 510080, Guangdong, Peoples R China

[4] S China Univ Technol, Coll Mat Sci & Engn, Guangzhou 510641, Guangdong, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2013年 / 92卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Chitosan; PNIPAAm; Comb-shape; pH/temperature multi-responsive; ATRP; TRANSFER RADICAL POLYMERIZATION; HYDROXYPROPYL CELLULOSE BACKBONES; SIDE-CHAINS; ATRP; POLY(N-ISOPROPYLACRYLAMIDE); MACROMONOMERS; NANOPARTICLES; ARCHITECTURE; FABRICATION; COMPLEXES;

D O I：

10.1016/j.carbpol.2012.09.014

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Comb-shaped copolymers comprised of hydrophobic and hydrophilic blocks are self-assembled in aqueous solution, which results that they are suitable for delivery of hydrophobic drug molecules. Chitosan (CS) is an important biomaterial used widely in medical applications. Herein, a comb-shaped cationic copolymer composed of long biocompatible CS main chains and short PNIPAAm side chains was prepared via atom transfer radical polymerization (ATRP) by attaching an ATRP initiating group to N-phthaloyl chitosan. By subsequent removal of the protective groups on N-phthaloyl chitosan-graft-poly(N-isopropylacrylamide) (PHCS-g-PNIPAAm) copolymer with N2H4 center dot H2O lead to the polymer pendant amino groups, this study attempted to synthesize a pH/temperature multi-responsive material. This chitosan-graft-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) copolymer is self-assembled in aqueous solution into stimuli-responsive core-shell micelles with hydrodynamic diameters of about 170 nm. Structural organization and solution behavior were then investigated utilizing H-1 NMR spectroscopy, transmission electron microscopy (TEM) and dynamic light scattering (DLS). (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：621 / 628

页数：8

共 41 条

[1]

Thermo-Responsive Association of Chitosan-graft-Poly(N-isopropylacrylamide) in Aqueous Solutions [J].