Zn impacts Cu coordination to amyloid-β, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity

被引：61

作者：

Alies, Bruno ^{[1
,2
]}

Sasaki, Isabelle ^{[1
,2
]}

Proux, Olivier ^{[3
,4
]}

Sayen, Stephanie ^{[5
]}

Guillon, Emmanuel ^{[5
]}

Faller, Peter ^{[1
,2
]}

Hureau, Christelle ^{[1
,2
]}

机构：

[1] CNRS, LCC, F-31077 Toulouse, France

[2] Univ Toulouse, UPS, INPT, LCC, F-31077 Toulouse, France

[3] CNRS, Observ Sci Univers Grenoble, F-38041 Grenoble 9, France

[4] Univ Grenoble 1, F-38041 Grenoble 9, France

[5] Univ Reims, Grp Chim Coordinat, CNRS, ICMR,UMR 7312, F-51687 Reims 2, France

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 12期

关键词：

ACTIVE METAL-IONS; PRECURSOR PROTEIN; BINDING-SITES; PRION PROTEIN; A-BETA; COPPER; ZINC; ENVIRONMENT; COMPLEXES; DISEASE;

D O I：

10.1039/c2cc38236a

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Combined coordination of Zn-II and Cu-I or Cu-II to the amyloid-beta peptide has been investigated using XANES, EPR and NMR spectroscopies. While ZnII does alter Cu-II binding to A beta, this has no effect on (A beta)Cu induced ROS production and associated cell toxicity.

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收藏

页码：1214 / 1216

页数：3

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