A spatial approach to transcriptional profiling: mechanotransduction and the focal origin of atherosclerosis

被引：79

作者：

Davies, PF ^{[1
]}

Polacek, DC

Handen, JS

Helmke, BP

DePaola, N

机构：

[1] Univ Penn, Inst Med & Engn, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

[4] Rensselaer Polytech Inst, Dept Biomed Engn, Troy, NY 12180 USA

来源：

TRENDS IN BIOTECHNOLOGY | 1999年 / 17卷 / 09期

关键词：

D O I：

10.1016/S0167-7799(99)01348-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

The initiation and progression of focal atherosclerotic lesions has long been known to be associated with regions of disturbed blood flow. Improved precision in experimental models of spatially defined flow has recently been combined with regional and single-cell gene-expression profiling to investigate the relationships linking haemodynamics to vessel-walt pathobiology.

引用

页码：347 / 351

页数：5

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