Pharmacokinetic studies of I-131-stevioside and its metabolites

被引：23

作者：

Cardoso, VN

Barbosa, MF

Muramoto, E

Mesquita, CH

Almeida, MA

机构：

[1] UNIV FED MINAS GERAIS,FAC PHARM,DEPT FOOD,SAO PAULO,BRAZIL

[2] CNEN,IPEN,RADIOPHARM DIV,SAO PAULO,BRAZIL

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1996年 / 23卷 / 01期

关键词：

I-131-stevioside; metabolites; Wistar rat;

D O I：

10.1016/0969-8051(95)02072-1

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 [临床医学]; 100207 [影像医学与核医学]; 1009 [特种医学];

摘要：

I-131-STEVIOSIDE (1.10 MBq) was injected i.v in Wistar male rats, in distribution in the body and metabolism were studied. The highest concentration of radioactivity was observed in the liver and in the small intestine after 10 and 120 minutes, respectively. At 2 h after injection, the radioactivity eliminated in the bile was 52.0% of the original dose. The results of RP-HPLC analysis of the bile showed that stevioside was degraded in vivo and that steviol appeared as a major metabolite. However, in the urine; RP-HPLC analysis did not show the presence of steviol.

引用

页码：97 / 100

页数：4

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