Meta-analysis of some results of clinical trials on sulodexide therapy in peripheral occlusive arterial disease

被引:30
作者
Gaddi, A [1 ]
Galetti, C [1 ]
Illuminati, B [1 ]
Nascetti, S [1 ]
机构
[1] POLICLIN S ORSOLA, CTR ATHEROSCLEROSIS STUDY & METAB DIS GIANCARLO D, S ORSOLA HOSP, I-40138 BOLOGNA, ITALY
关键词
sulodexide; glycosaminoglycans; meta-analysis; diabetes; peripheral occlusive arterial disease; viscosity; fibrinogen; claudication;
D O I
10.1177/030006059602400501
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The aim was to look at the effect of sulodexide in diabetic and non-diabetic patients with peripheral occlusive arterial disease (POAD), by verifying, through meta-analysis of Italian data, if the drug affects the clinical course of claudication or the main risk factors for POAD. Sulodexide increases the pain-free walking distance (benefit 36% vs controls, P < 0.001). The meta-analysis confirmed the effectiveness of sulodexide in improving claudication (lower limit of the 95% CI for overall odds ratio always >1). There was a marked effect in lowering triglycerides (overall -28%, P = 0.0015), fibrinogen (-13%, P < 0.0001) and plasma and serum viscosities, and in increasing high-density-lipoprotein cholesterol (24.4%, P = 0.0007). The medium-term administration of sulodexide has a therapeutic effect on claudication of diabetic and/or hyperlipidaemic patients suffering from POAD stages - and also counteracts several POAD risk factors. Long-term use of sulodexide appears to be well tolerated. The treatment has a low daily cost; therefore, it has a favourable cost-benefit ratio, in view of the high general costs associated with global POAD care, particularly in diabetic patients.
引用
收藏
页码:389 / 406
页数:18
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