QUERCETIN MODULATES Na+/K+ ATPASE AND SODIUM HYDROGEN EXCHANGER IN TYPE 2 DIABETIC ERYTHROCYTES

被引：41

作者：

Mishra, N. ^{[1
]}

Rizvi, S. I. ^{[2
]}

机构：

[1] Univ Allahabad, Ctr Food Technol, Allahabad 211002, Uttar Pradesh, India

[2] Univ Allahabad, Dept Biochem, Allahabad 211002, Uttar Pradesh, India

来源：

CELLULAR AND MOLECULAR BIOLOGY | 2012年 / 58卷 / 01期

关键词：

Diabetes; erythrocytes; quercetin; Na+/K+ ATPase; NHE; H+ ANTIPORT ACTIVITY; PROTEIN GLYCOSYLATION; LIPID-PEROXIDATION; OXIDATIVE STRESS; GENETIC-MARKER; FUSARIUM-WILT; CELL-VOLUME; K+ ATPASE; INSULIN; (NA++K+)-ATPASE;

D O I：

10.1170/T934

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Quercetin has been reported to possess many important biological properties. We undertook in vitro studies to examine the effect of quercetin on erythrocyte Na+/K+ ATPase and sodium hydrogen exchanger (NHE) activity in normal and type 2 diabetic subjects. A significant (p<0.02) increase in the activities of Na+/K+ ATPase and a decrease (p<0.01) in NHE were observed in type 2 diabetic subjects compared to normal. In vitro treatment with quercetin caused inhibition of both Na+/K+ ATPase and NHE. The inhibitory effect of quercetin was concentration dependent. The effect of quercetin on Na+/K+ ATPase and NHE may be explained due to a direct effect of this compound on plasma membrane leading to a change in membrane fluidity. The data obtained in this study may help to explain the anti-diabetic and anti-carcinogenic role of quercetin.

引用

页码：148 / 152

页数：5

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