Cytoplasmic vacuolization during exposure to drugs and other substances

被引：125

作者：

Aki, Toshihiko ^{[1
]}

Nara, Akina ^{[1
]}

Uemura, Koichi ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Sect Forens Med, Bunkyo Ku, Tokyo 1138519, Japan

来源：

CELL BIOLOGY AND TOXICOLOGY | 2012年 / 28卷 / 03期

基金：

日本学术振兴会;

关键词：

Autophagy; Endocytosis; ER stress; Lysosome; Lysosomotropicity; Vacuolization; CYTOCHROME-C RELEASE; MOUSE PERITONEAL-MACROPHAGES; APOPTOTIC CELL-DEATH; HELICOBACTER-PYLORI; CANCER-CELLS; PROTEASOME INHIBITION; GLIOBLASTOMA CELLS; INTRALYSOSOMAL PH; SMALL-MOLECULE; CALPHOSTIN-C;

D O I：

10.1007/s10565-012-9212-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Cytoplasmic vacuolization upon exposure to a variety of chemicals and bioactive substances has been extensively reported. Nearly 30 years have passed since the description by Nobel Laureate Christian de Duve of the mechanism underlying the lysosomal accumulation of lipophilic weak bases referred to these substances as lysosomotropic agents. It has now been revealed, however, that vacuolization occurs upon exposure to compounds other than lipophilic weak bases. Vacuolization of organelles/vesicles other than acidic compartments has also now been reported. In this mini-review, we provide an overview of the origin, mechanism, and possible outcomes of cellular vacuolization during exposure to substances with lysosomotropic as well as other properties.

引用

页码：125 / 131

页数：7

共 44 条

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