Perspectives on NMR in drug discovery: a technique comes of age

被引：304

作者：

Pellecchia, Maurizio ^{[1
]}

Bertini, Ivano ^{[2
]}

Cowburn, David ^{[3
]}

Dalvit, Claudio ^{[2
,4
]}

Giralt, Ernest ^{[5
,6
]}

Jahnke, Wolfgang ^{[7
]}

James, Thomas L. ^{[8
]}

Homans, Steve W. ^{[9
]}

Kessler, Horst ^{[10
]}

Luchinat, Claudio

Meyer, Bernd ^{[11
]}

Oschkinat, Hartmut ^{[12
]}

Peng, Jeff ^{[13
]}

Schwalbe, Harald ^{[14
]}

Siegal, Gregg ^{[15
]}

机构：

[1] Burnham Inst Med Res, La Jolla, CA 92037 USA

[2] Univ Florence, Magnet Resonance Ctr, I-50019 Sesto Fiorentino, Italy

[3] New York Struct Biol Ctr, New York, NY 10027 USA

[4] CNIO, Expt Therapeut Programme, Madrid 28029, Spain

[5] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain

[6] Univ Barcelona, Biomed Res Inst, E-08028 Barcelona, Spain

[7] Novartis Inst BioMed Res, CH-4002 Basel, Switzerland

[8] Univ Calif San Francisco, Sch Pharm, San Francisco, CA 94158 USA

[9] Univ Leeds, Inst Mol & Cellular Biol, Leeds LS2 9JT, W Yorkshire, England

[10] Tech Univ Munich, Ctr Integrated Prot Sci, D-85747 Munich, Germany

[11] Univ Hamburg, Inst Organ Chem, D-20146 Hamburg, Germany

[12] Forsch Inst Mol Pharmakol, D-13125 Berlin, Germany

[13] Univ Notre Dame, Notre Dame, IN 46556 USA

[14] Ctr Biomol Magnet Resonance, D-60438 Frankfurt, Germany

[15] Leiden Univ, Inst Chem, NL-2300 RA Leiden, Netherlands

来源：

NATURE REVIEWS DRUG DISCOVERY | 2008年 / 7卷 / 09期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1038/nrd2606

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

In the past decade, the potential of harnessing the ability of nuclear magnetic resonance (NMR) spectroscopy to monitor intermolecular interactions as a tool for drug discovery has been increasingly appreciated in academia and industry. in this Perspective, we highlight some of the major applications of NMR in drug discovery, focusing on hit and lead generation, and provide a critical analysis of its current and potential utility.

引用

页码：738 / 745

页数：8

共 119 条

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DESIGN, SYNTHESIS, AND CHARACTERIZATION OF A POTENT XYLOSE ISOMERASE INHIBITOR, D-THREONOHYDROXAMIC ACID, AND HIGH-RESOLUTION X-RAY CRYSTALLOGRAPHIC STRUCTURE OF THE ENZYME-INHIBITOR COMPLEX [J].