Myositis autoantibodies

被引：104

作者：

Casciola-Rosen, Livia ^{[2
]}

Mammen, Andrew L. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

来源：

CURRENT OPINION IN RHEUMATOLOGY | 2012年 / 24卷 / 06期

关键词：

autoantibodies; autoantigens; dermatomyositis; myositis; necrotizing myopathy; SIGNAL-RECOGNITION PARTICLE; IDIOPATHIC INFLAMMATORY MYOPATHY; CLINICALLY AMYOPATHIC DERMATOMYOSITIS; MEDIATED NECROTIZING MYOPATHY; REGENERATING MUSCLE; RIG-I; AUTOANTIGEN; ANTIBODIES; PROTEIN; ASSOCIATION;

D O I：

10.1097/BOR.0b013e328358bd85

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Purpose of review To review recent advances in our understanding of autoantibodies associated with dermatomyositis and the autoimmune necrotizing myopathies. Recent findings Autoantibodies preferentially associated with dermatomyositis include those recognizing Mi-2, MDA5, TIF1 gamma, and NXP-2. Each of these is associated with a distinct clinical phenotype. Autoantibodies found in patients with autoimmune necrotizing myopathies recognize signal recognition particle and 3-hydroxy-3-methylglutaryl-coenzime A reductase (HMG-CoA) reductase. The latter are found in patients with statin-associated autoimmune muscle disease. Summary As these are helpful both diagnostically and prognostically, a rheumatologist should be familiar with autoantibodies found in patients with dermatomyositis and the autoimmune necrotizing myopathies.

引用

页码：602 / 608

页数：7

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