Infectious mononucleosis and risk for multiple sclerosis: A meta-analysis

被引：350

作者：

Thacker, EL

Mirzaei, F

Ascherio, A

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

来源：

ANNALS OF NEUROLOGY | 2006年 / 59卷 / 03期

关键词：

D O I：

10.1002/ana.20820

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To characterize the association between infectious mononucleosis (IM), a frequent clinical manifestation of primary Epstein-Barr virus infection after childhood, and the risk for multiple sclerosis (MS). Methods We conducted a systematic review and meta-analysis of case-control and cohort studies of IM and MS. Results. The combined relative risk of MS after IM from 14 studies was 2.3 (95% confidence interval, 1.7-3.0; p < 10(-8)). Potential sources of heterogcncity (ie, study design, MS definition, and latitude) barely influenced our results. Interpretation: We conclude that Epstein-Barr virus infection manifesting as IM in adolescents and young adults is a risk factor for MS.

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页码：499 / 503

页数：5

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