Protection by Immunoglobulin Dual-Affinity Retargeting Antibodies against Dengue Virus

被引：16

作者：

Brien, James D. ^{[1
]}

Sukupolvi-Petty, Soila ^{[1
]}

Williams, Katherine L. ^{[4
]}

Lam, Chia-Ying Kao ^{[5
]}

Schmid, Michael A. ^{[4
]}

Johnson, Syd ^{[5
]}

Harris, Eva ^{[4
]}

Diamond, Michael S. ^{[1
,2
,3
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

[4] Univ Calif Berkeley, Sch Publ Hlth, Div Infect Dis & Vaccinol, Berkeley, CA 94720 USA

[5] MacroGenics Inc, Rockville, MD USA

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 13期

关键词：

PROTEIN DOMAIN-III; T-CELL RESPONSES; ENVELOPE PROTEIN; MONOCLONAL-ANTIBODY; HEMORRHAGIC-FEVER; NEUTRALIZING EPITOPE; IN-VITRO; GLYCOPROTEIN; SEROTYPES; MECHANISM;

D O I：

10.1128/JVI.00327-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Dengue viruses are the most common arthropod-transmitted viral infection, with an estimated 390 million human infections annually and similar to 3.6 billion people at risk. Currently, there are no approved vaccines or therapeutics available to control the global dengue virus disease burden. In this study, we demonstrate the binding, neutralizing activity, and therapeutic capacity of a novel bispecific dual-affinity retargeting molecule (DART) that limits infection of all four serotypes of dengue virus.

引用

页码：7747 / 7753

页数：7

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