Antitumor sterols from the mycelia of Cordyceps sinensis

被引：479

作者：

Bok, JW

Lermer, L

Chilton, J

Klingeman, HG

Towers, GHN ^{[1
]}

机构：

[1] Univ British Columbia, Dept Bot, Vancouver, BC V6T 1Z4, Canada

[2] N Amer Reishi, Gibsons, BC V0N 1V0, Canada

[3] Univ British Columbia, Dept Med, Terry Fox Lab, Vancouver, BC V5X 1C3, Canada

来源：

PHYTOCHEMISTRY | 1999年 / 51卷 / 07期

关键词：

Cordyceps sinenis; antitumor activity; steroidal glycosides;

D O I：

10.1016/S0031-9422(99)00128-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Activity guided fractionations led to the isolation of two antitumor compounds 5 alpha,8 alpha-epidioxy-24(R)-methylcholesta-6,22-dien-3 beta-D-glucopyranoside and 5,6-epoxy-24(R)-methylcholesta-7,22-dien-3 beta-ol from the methanol extract of Cordyceps sinensis. Two previously known compounds, ergosteryl-3-O-beta-D-glucopyranoside and 22-dihydroergosteryl-3-O-beta-D-glucopyranoside were also isolated. The structures of hitherto unknown sterols were established by 1D and 2D NMR spectroscopic techniques with the former synthesized in order to confirm the identity of the sugar moiety by chemical correlation. The glycosylated form of ergosterol peroxide was found to be a greater inhibitor to the proliferation of K562, Jurkat, WM-1341, HL-60 and RPMI-8226 tumor cell lines by 10 to 40% at 10 mu g/ml than its previously identified aglycone, 5 alpha,8 alpha-epidioxy-24(R)-methylcholesta-6,22-dien-3 beta-ol. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：891 / 898

页数：8

共 35 条

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