Proliferative marker Ki-67 in gallbladder carcinomas: high expression level predicts early recurrence after surgical resection

被引：14

作者：

Hui, AM ^{[1
]}

Shi, YZ ^{[1
]}

Li, X ^{[1
]}

Sun, L ^{[1
]}

Guido, T ^{[1
]}

Takayama, T ^{[1
]}

Makuuchi, M ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Surg, Hepato Biliary Pancreat Surg Div,Bunkyo Ku, Tokyo 1130033, Japan

来源：

CANCER LETTERS | 2002年 / 176卷 / 02期

基金：

日本学术振兴会;

关键词：

gallbladder cancer; proliferation; prognosis;

D O I：

10.1016/S0304-3835(01)00749-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To evaluate the prognostic value of proliferative maker Ki-67, its expression was determined immunohistochemically in 37 gallbladder carcinomas (GBCs). A high Ki-67 index was significantly correlated with tumor lymphatic invasion (P = 0.007) and vascular invasion (P = 0.04). High Ki-67 index group and low Ki-67 index group showed different clinical courses. Five patients who experienced recurrences in high Ki-67 index group developed their recurrent diseases within one year after surgery and died soon after recurrence, while the recurrences (five cases) in low Ki-67 index group were distributed all stages after surgery. In conclusion, high Ki-67 index predicts early recurrence after surgery for GBCs. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：191 / 198

页数：8

共 40 条

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