Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma

被引：772

作者：

Arzumanyan, Alla ^{[1
,2
]}

Reis, Helena M. G. P. V. ^{[3
]}

Feitelson, Mark A. ^{[1
,2
]}

机构：

[1] Temple Univ, Coll Sci & Technol, Dept Biol, Philadelphia, PA 19122 USA

[2] Temple Univ, Coll Sci & Technol, Sbarro Hlth Res Org, Philadelphia, PA 19122 USA

[3] MIT Portugal Program, P-1049001 Lisbon, Portugal

来源：

NATURE REVIEWS CANCER | 2013年 / 13卷 / 02期

基金：

美国国家卫生研究院;

关键词：

HEPATITIS-B-VIRUS; EPITHELIAL-MESENCHYMAL TRANSITION; GROWTH-FACTOR RECEPTOR; NF-KAPPA-B; HYPOXIA-INDUCIBLE FACTORS; C VIRUS; X-PROTEIN; CORE PROTEIN; OXIDATIVE STRESS; UP-REGULATION;

D O I：

10.1038/nrc3449

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Hepatocellular carcinoma (HCC) is a highly lethal cancer, with increasing worldwide incidence, that is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infections. There are few effective treatments partly because the cell- and molecular-based mechanisms that contribute to the pathogenesis of this tumour type are poorly understood. This Review outlines pathogenic mechanisms that seem to be common to both viruses and which suggest innovative approaches to the prevention and treatment of HCC.

引用

收藏

页码：123 / 135

页数：13

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