Amniotic fluid soluble human leukocyte antigen G is markedly decreased in offspring with neural tube defects

被引：18

作者：

Emmer, PM

Steegers, EAP

van Lierop, MJ

Steegers-Theunissen, RPM

Loke, YW

Joosten, I

机构：

[1] Univ Med Ctr Nijmegen, Dept Bloodtransfus & Transplantat Immunol, NL-6500 HB Nijmegen, Netherlands

[2] Univ Med Ctr Nijmegen, Dept Obstet & Gynaecol, Nijmegen, Netherlands

[3] Organon, Oss, Netherlands

[4] Univ Med Ctr Nijmegen, Dept Epidemiol & Biostat, Nijmegen, Netherlands

[5] Univ Cambridge, Dept Pathol, Res Grp Human Reprod Immunobiol, Cambridge CB2 1QP, England

来源：

EARLY HUMAN DEVELOPMENT | 2002年 / 66卷 / 02期

关键词：

HLA-G; amniotic fluid; neural tube defects;

D O I：

10.1016/S0378-3782(01)00236-5

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Pregnancies affected by a neural tube defect show changes in thymus morphology, neonatal and maternal T-cell repertoire. Amniotic fluid levels of soluble human leukocyte antigen G (HLA-G) (an immuno-modulatoty protein) were found to be significantly lower as compared to controls. This may reflect a diminished cell-mediated immunity in neural tube defects. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：101 / 105

页数：5

共 9 条

[1]

Soluble HLA-G1 triggers CD95/CD95 ligand-mediated apoptosis in activated CD8+ cells by interacting with CD8 [J].