Endothelin-1 stimulates DNA synthesis of vascular smooth-muscle cells through transactivation of epidermal growth factor receptor

被引：27

作者：

Iwasaki, H ^{[1
]}

Eguchi, S ^{[1
]}

Marumo, F ^{[1
]}

Hirata, Y ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Dept Internal Med 2, Div Endocrine Hypertens, Bunkyo Ku, Tokyo 113, Japan

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1998年 / 31卷

关键词：

endothelin-1; epidermal growth factor receptor; c-Fos; DNA synthesis;

D O I：

10.1097/00005344-199800001-00052

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To elucidate the molecular mechanism of the mitogenic effect of endothelin-1(ET-1) on vascular smooth-muscle cells (VSMCs), we studied the effect of AG1478, a novel epidermal growth factor receptor (EGFR) kinase inhibitor, on p42/44 mitogen-activated protein (MAP) kinase activation, c-Fos expression, and DNA synthesis stimulated by ET-1. AG1478 dose-dependently (2.5 x 10(-8) M-2.5 x 10(-7) M) inhibited ET-1-induced MAP kinase activation. The ET-1-induced c-Fos protein expression was inhibited by AG1478 (2.5 x 10(-7) M). AG1478 also dose-dependently inhibited ET-1-stimulated [H-3]thymidine incorporation. These data suggest that ET-1 induces MAP kinase activation, c-Fos expression, and promotes proliferation of VSMCs via transactivation of EGFR.

引用

页码：S182 / S184

页数：3

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