Paramagnetic lanthanide complexes as PARACEST agents for medical imaging

被引：315

作者：

Woods, Mark

Woessner, Donald E.

Sherry, A. Dean

机构：

[1] Univ Texas, Dept Chem, Richardson, TX 75080 USA

[2] Macrocyclics, Dallas, TX 75235 USA

[3] Univ Texas, SW Med Ctr, Adv Imaging Res Ctr, Dallas, TX 75390 USA

[4] Univ Texas, SW Med Ctr, Adv Imaging Res Ctr, Dallas, TX 75390 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2006年 / 35卷 / 06期

关键词：

D O I：

10.1039/b509907m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This tutorial review examines the fundamental aspects of a new class of contrast media for MRI based upon the chemical shift saturation transfer (CEST) mechanism. Several paramagnetic versions called PARACEST agents have shown utility as responsive agents for reporting physiological or metabolic information by MRI. It is shown that basic NMR exchange theory can be used to predict how parameters such as chemical shift, bound water lifetimes, and relaxation rates can be optimized to maximize the sensitivity of PARACEST agents.

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收藏

页码：500 / 511

页数：12

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