Salivary cortisol as a biomarker in stress research

被引：1294

作者：

Hellhammer, Dirk H. ^{[1
]}

Wuest, Stefan ^{[1
,2
]}

Kudielka, Brigitte M. ^{[1
,3
]}

机构：

[1] Univ Trier, Dept Clin & Physiol Psychol, D-54290 Trier, Germany

[2] Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, D-68159 Mannheim, Germany

[3] Jacobs Univ Bremen, Jacobs Ctr Lifelong Learning & Inst Dev, D-28759 Bremen, Germany

来源：

PSYCHONEUROENDOCRINOLOGY | 2009年 / 34卷 / 02期

关键词：

Stress response; Cortisol; CRF; AVP; ACTH; GLUCOCORTICOID-RECEPTOR GENE; CORTICOTROPIN-RELEASING HORMONE; ORAL-CONTRACEPTIVES; PSYCHOSOCIAL STRESS; BCLI POLYMORPHISM; RESISTANT ASTHMA; GONADAL-STEROIDS; AXIS RESPONSES; IN-VIVO; SENSITIVITY;

D O I：

10.1016/j.psyneuen.2008.10.026

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Salivary cortisol is frequently used as a biomarker of psychological stress. However, psychobiological mechanisms, which trigger the hypothalamus-pituitary-adrenal axis (HPAA) can only indirectly be assessed by salivary cortisol measures. The different instances that control HPAA reactivity (hippocampus, hypothalamus, pituitary, adrenals) and their respective modulators, receptors, or binding proteins, may all affect salivary cortisol measures. Thus, a linear relationship with measures of plasma ACTH and cortisol in blood or urine does not necessarily exist. This is particularly true under response conditions. The present paper addresses several psychological and biological variables, which may account for such dissociations, and aims to help researchers to rate the validity and psychobiological significance of salivary cortisol as an HPAA biomarker of stress in their experiments. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：163 / 171

页数：9

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