Vibro-acoustography: An imaging modality based on ultrasound-stimulated acoustic emission

被引:332
作者
Fatemi, M [1 ]
Greenleaf, JF [1 ]
机构
[1] Mayo Clin & Mayo Fdn, Dept Physiol & Biophys, Rochester, MN 55905 USA
关键词
D O I
10.1073/pnas.96.12.6603
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We describe theoretical principles of an imaging modality that uses the acoustic response of an object to a highly localized dynamic radiation force of an ultrasound field. In this method, named ultrasound-stimulated vibro-acoustography (USVA), ultrasound is used to exert a low-frequency (in kHz range) force on the object. In response, a portion of the object vibrates sinusoidally in a pattern determined by its viscoelastic properties. The acoustic emission field resulting from object vibration is detected and used to form an image that represents both the ultrasonic and low-frequency (kHz range) mechanical characteristics of the object. We report the relation between the emitted acoustic field and the incident ultrasonic pressure field in terms of object parameters. Also, we present the point-spread function of the imaging system. The experimental images in this report have a resolution of about 700 mu m, high contrast, and high signal-to-noise ratio. USVA is sensitive enough to detect object motions on the order of nanometers. Possible applications include medical imaging and material evaluation.
引用
收藏
页码:6603 / 6608
页数:6
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