DNA DAMAGE - OPINION Charity begins at home: non-coding RNA functions in DNA repair

被引：113

作者：

Chowdhury, Dipanjan ^{[1
]}

Choi, Young Eun ^{[1
]}

Brault, Marie Eve ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Genom Stabil & DNA Repair,Dept Radiat Oncol, Boston, MA 02215 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2013年 / 14卷 / 03期

关键词：

DOUBLE-STRAND BREAK; MICRORNA BINDING-SITES; TUMOR-SUPPRESSOR; HOMOLOGOUS RECOMBINATION; ULTRACONSERVED REGIONS; BRCA1; EXPRESSION; DOWN-REGULATION; MESSENGER-RNAS; UP-REGULATION; P53; NETWORK;

D O I：

10.1038/nrm3523

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

During the past decade, evolutionarily conserved microRNAs (miRNAs) have been characterized as regulators of almost every cellular process and signalling pathway. There is now emerging evidence that this new class of regulators also impinges on the DNA damage response (DDR). Both miRNAs and other small non-coding RNAs (ncRNAs) are induced at DNA breaks and mediate the repair process. These intriguing observations raise the possibility that crosstalk between ncRNAs and the DDR might provide a means of efficient and accurate DNA repair and facilitate the maintenance of genomic stability.

引用

收藏

页码：181 / 189

页数：9

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