ATRX and the replication of structured DNA

被引：45

作者：

Clynes, David ^{[1
]}

Gibbons, Richard J. ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, MRC,Mol Haematol Unit, Oxford OX3 9DS, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2013年 / 23卷 / 03期

基金：

英国医学研究理事会;

关键词：

HISTONE CHAPERONE; CHROMATIN; TELOMERES; H3.3; DAXX; MUTATIONS; PROTEIN; LOCALIZATION; EXPRESSION; DEPOSITION;

D O I：

10.1016/j.gde.2013.01.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Understanding the underlying molecular basis for disease can often be a prolonged and tortuous process with many false leads and blind alleys. Relating the cause of ATR-X syndrome to the function of the protein ATRX is a case in point. In this review we attempt to bring together the diverse biological phenomena associated with ATRX dysfunction with what has recently been discovered concerning the chromatin remodelling activity of this protein. This potentially casts light on how defective DNA replication/histone replacement can impact on transcription, telomere maintenance and also possibly chromosome segregation.

引用

收藏

页码：289 / 294

页数：6

相关论文

共 35 条

[1]

Histone H3 variants specify modes of chromatin assembly [J].

Ahmad, K ;

Henikoff, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 :16477-16484

[2]

Non-B DNA Conformations as Determinants of Mutagenesis and Human Disease [J].

Bacolla, Albino ;

Wells, Robert D. .

MOLECULAR CARCINOGENESIS, 2009, 48 (04) :273-285

[3]

Loss of Maternal ATRX Results in Centromere Instability and Aneuploidy in the Mammalian Oocyte and Pre-Implantation Embryo [J].

Baumann, Claudia ;

Viveiros, Maria M. ;

De la Fuente, Rabindranath .

PLOS GENETICS, 2010, 6 (09)

[4]

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines [J].

Bryan, TM ;

Englezou, A ;

DallaPozza, L ;

Dunham, MA ;

Reddel, RR .

NATURE MEDICINE, 1997, 3 (11) :1271-1274

[5]

ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes [J].

De La Fuente, R ;

Viveiros, MM ;

Wigglesworth, K ;

Eppig, JJ .

DEVELOPMENTAL BIOLOGY, 2004, 272 (01) :1-14

[6]

Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors [J].

de Wilde, Roeland F. ;

Heaphy, Christopher M. ;

Maitra, Anirban ;

Meeker, Alan K. ;

Edil, Barish H. ;

Wolfgang, Christopher L. ;

Ellison, Trevor A. ;

Schulick, Richard D. ;

Molenaar, I. Quintus ;

Valk, Gerlof D. ;

Vriens, Menno R. ;

Rinkes, Inne H. M. Borel ;

Offerhaus, G. Johan A. ;

Hruban, Ralph H. ;

Matsukuma, Karen E. .

MODERN PATHOLOGY, 2012, 25 (07) :1033-1039

[7]

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3 [J].

Drane, Pascal ;

Ouararhni, Khalid ;

Depaux, Arnaud ;

Shuaib, Muhammad ;

Hamiche, Ali .

GENES & DEVELOPMENT, 2010, 24 (12) :1253-1265

[8]

SYNDROMAL MENTAL-RETARDATION DUE TO MUTATIONS IN A REGULATOR OF GENE-EXPRESSION [J].

GIBBONS, RJ ;

PICKETTS, DJ ;

HIGGS, DR .

HUMAN MOLECULAR GENETICS, 1995, 4 :1705-1709

[9]

Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation [J].

Gibbons, RJ ;

McDowell, TL ;

Raman, S ;

O'Rourke, DM ;

Garrick, D ;

Ayyub, H ;

Higgs, DR .

NATURE GENETICS, 2000, 24 (04) :368-371

[10]

How telomeres are replicated [J].

Gilson, Eric ;

Geli, Vincent .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (10) :825-838

← 1 2 3 4 →