Thymus exosomes-like particles induce regulatory T cells

被引：117

作者：

Wang, Gui-Jun ^{[1
,4
]}

Liu, Yuelong ^{[1
,4
]}

Qin, Aijian ^{[4
]}

Shah, Spandan V. ^{[1
]}

Deng, Zhong-bin ^{[1
]}

Xiang, Xiaoyu ^{[1
]}

Cheng, Ziqiang ^{[1
]}

Liu, Cunren ^{[1
]}

Wang, Jianhua ^{[1
]}

Zhang, Liming ^{[1
]}

Grizzle, William E. ^{[2
]}

Zhang, Huang-Ge ^{[1
,3
]}

机构：

[1] Univ Alabama, Div Clin Immunol & Rheumatol, Dept Med, Birmingham, AL 35294 USA

[2] Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA

[3] Vet Adm Med Ctr, Birmingham, AL 35233 USA

[4] Yangzhou Univ, Coll Vet Med, Yangzhou, Peoples R China

来源：

JOURNAL OF IMMUNOLOGY | 2008年 / 181卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.4049/jimmunol.181.8.5242

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Exosomes released from different types of cells have been proposed to contribute to intercellular communication. We report that thymic exosome-like particles (ELPs) released from cells of the thymus can induce the development of Foxp3(+) regulatory T (Treg) cells in the lung and liver. Thymic ELPs also induce the conversion of thymic CD4(+)CD25(-) T cells into Tregs. Tregs induced by thymic ELPs suppress the proliferation of CD4(+)CD25(-) T cells in vitro and in vivo. We further show that neutralization of TGF-beta in ELPs partially reverses thymic ELP-mediated induction of CD4(+)Foxp3(+) T cells in the lung and liver. This study demonstrates that thymic ELPs participate in the induction of Foxp3(+) Tregs. Also, TGF-beta of thymic ELPs might be required for the generation of Tregs in the peripheral tissues.

引用

收藏

页码：5242 / 5248

页数：7

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