Elevated profiles of Th22 cells and correlations with Th17 cells in patients with immune thrombocytopenia

被引：176

作者：

Hu, Yu ^{[1
]}

Li, Haiyan ^{[4
]}

Zhang, Lei ^{[2
]}

Shan, Baozhong ^{[3
]}

Xu, Xingfang ^{[5
]}

Li, Hong ^{[3
]}

Liu, Xinguang ^{[1
]}

Xu, Shuqian ^{[1
]}

Yu, Shuang ^{[1
]}

Ma, Daoxin ^{[1
]}

Peng, Jun ^{[1
]}

Hou, Ming ^{[1
,6
,7
]}

机构：

[1] Shandong Univ, Qilu Hosp, Dept Hematol, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Qilu Hosp, Dept Orthoped, Jinan 250012, Shandong, Peoples R China

[3] Shandong Univ, Jinan Cent Hosp, Dept Stomatol, Jinan 250013, Peoples R China

[4] Hosp Univ Jinan, Dept Internal Med, Jinan 250022, Peoples R China

[5] Qihe Cty Hosp, Dept Internal Med, Qihe 251100, Peoples R China

[6] Shandong Univ, Key Lab Cardiovasc Remodelling & Funct Res, Chinese Minist Educ, Qilu Hosp, Jinan 250012, Shandong, Peoples R China

[7] Shandong Univ, Key Lab Cardiovasc Remodelling & Funct Res, Chinese Minist Hlth, Qilu Hosp, Jinan 250012, Shandong, Peoples R China

来源：

HUMAN IMMUNOLOGY | 2012年 / 73卷 / 06期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

GROWTH-FACTOR-BETA; T-CELLS; INDUCIBLE FACTOR; INTERLEUKIN; 22; PURPURA; IL-22; CYTOKINE; DISTINCT; RESPONSES; PATHWAYS;

D O I：

10.1016/j.humimm.2012.04.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

T-helper (Th) 22 and Th17 cells are implicated in the pathogenesis of autoimmune diseases. However, the role of Th22 cells in the pathophysiology of immune thrombocytopenia (ITP) remains unclear. Th22, Th17 and Th1 cells in both ITP patients and healthy controls were examined by flow cytometry. Plasma interleukin-22 (IL-22) level was measured by enzyme linked immunosorbent assay (ELISA). Signal transducers and activators of transcription 3 (STAT-3) and transcription factor RAR-related organ receptor C (RORC) messenger RNA (mRNA) expressions were examined by quantitative reverse transcription polymerase chain reaction (RT-PCR). Th22 cells, Th17 cells, Th1 cells and plasma 11-22 were significantly higher in ITP patients than in healthy controls. Moreover, Th22 cells showed a positive correlation with the levels of plasma IL-22 as well as Th17 and Th1 cells in ITP patients. Significant up-regulations of both STAT-3 and RORC transcription factors were also observed. Additionally, the percentage of Th22 cells was higher in autoantibody-negative ITP patients than in autoantibody-positive patients. Our results demonstrate a possible role of Th22 cells in ITP, and thus, the blockade of IL-22 may be a reasonable therapeutic strategy for ITP. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：629 / 635

页数：7

共 33 条

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IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration [J].