Synthesis of some new biologically-active coumarin derivatives

被引：22

作者：

El-Sayed, AM ^{[1
]}

Ghattas, ABAG ^{[1
]}

El-Wassimy, MT ^{[1
]}

Allah, OAA ^{[1
]}

机构：

[1] S Valley Univ, Fac Sci, Dept Chem, Sohag, Egypt

来源：

FARMACO | 1999年 / 54卷 / 1-2期

关键词：

thiocoumarins; coumarin hydrazones; benzopyranopyrazoles; biological activity;

D O I：

10.1016/S0014-827X(98)00099-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Coumarin and 6-nitrocoumarin hydrazones (2a,b), respectively, were prepared via the reaction of 2-thiocoumarin (1a,b) derivatives with hydrazine hydrate. The hydrazones were used as key intermediates for the preparation of some benzopyrano-[2,3-c]pyrazoles (21-24) through the reaction of different acyl halides and subsequent cyclization in N,N-dimethylaniline. Benzopyrano[2, 3-c]pyrazole-3-thione (25a,b) was prepared by the reaction of la with CS, on which some alkylation, acylation and Mannich reactions were studied. Alternative procedures, other reactions and biological activity of some new compounds were given. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：56 / 63

页数：8