Helicobacter pylori Colonization Ameliorates Glucose Homeostasis in Mice through a PPAR γ-Dependent Mechanism
被引:31
作者:
Bassaganya-Riera, Josep
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Virginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USA
Virginia Tech, Dept Biomed Sci & Pathobiol, VA MD Reg Coll Vet Med, Blacksburg, VA USAVirginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USA
Bassaganya-Riera, Josep
[1
,4
]
Dominguez-Bello, Maria Gloria
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Univ Puerto Rico, Dept Biol, San Juan, PR 00936 USAVirginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USA
Dominguez-Bello, Maria Gloria
[2
]
Kronsteiner, Barbara
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Virginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USAVirginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USA
Kronsteiner, Barbara
[1
]
Carbo, Adria
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Virginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USAVirginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USA
Carbo, Adria
[1
]
Lu, Pinyi
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Virginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USAVirginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USA
Lu, Pinyi
[1
]
Viladomiu, Monica
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Virginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USAVirginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USA
Viladomiu, Monica
[1
]
Pedragosa, Mireia
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Virginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USAVirginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USA
Pedragosa, Mireia
[1
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Zhang, Xiaoying
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Virginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USAVirginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USA
Zhang, Xiaoying
[1
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Sobral, Bruno W.
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Virginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USAVirginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USA
Sobral, Bruno W.
[1
]
Mane, Shrinivasrao P.
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Virginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USAVirginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USA
Mane, Shrinivasrao P.
[1
]
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Mohapatra, Saroj K.
[1
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Horne, William T.
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Virginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USAVirginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USA
Horne, William T.
[1
]
Guri, Amir J.
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Virginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USAVirginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USA
Guri, Amir J.
[1
]
Groeschl, Michael
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Univ Erlangen Nurnberg, D-91054 Erlangen, GermanyVirginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USA
Groeschl, Michael
[3
]
Lopez-Velasco, Gabriela
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Virginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USAVirginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USA
Lopez-Velasco, Gabriela
[1
]
Hontecillas, Raquel
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Virginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USAVirginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USA
Hontecillas, Raquel
[1
]
机构:
[1] Virginia Tech, Nutr Immunol & Mol Med Lab, Ctr Modeling Immun Enter Pathogens, Virginia Bioinformat Inst, Blacksburg, VA USA
[2] Univ Puerto Rico, Dept Biol, San Juan, PR 00936 USA
Background: There is an inverse secular trend between the incidence of obesity and gastric colonization with Helicobacter pylori, a bacterium that can affect the secretion of gastric hormones that relate to energy homeostasis. H. pylori strains that carry the cag pathogenicity island (PAI) interact more intimately with gastric epithelial cells and trigger more extensive host responses than cag(-) strains. We hypothesized that gastric colonization with H. pylori strains differing in cag PAI status exert distinct effects on metabolic and inflammatory phenotypes. Methodology/Principal Findings: To test this hypothesis, we examined metabolic and inflammatory markers in db/db mice and mice with diet-induced obesity experimentally infected with isogenic forms of H. pylori strain 26695: the cag PAI wild-type and its cag PAI mutant strain 99-305. H. pylori colonization decreased fasting blood glucose levels, increased levels of leptin, improved glucose tolerance, and suppressed weight gain. A response found in both wild-type and mutant H. pylori strain-infected mice included decreased white adipose tissue macrophages (ATM) and increased adipose tissue regulatory T cells (Treg) cells. Gene expression analyses demonstrated upregulation of gastric PPAR gamma-responsive genes (i.e., CD36 and FABP4) in H. pylori-infected mice. The loss of PPAR gamma in immune and epithelial cells in mice impaired the ability of H. pylori to favorably modulate glucose homeostasis and ATM infiltration during high fat feeding. Conclusions/Significance: Gastric infection with some commensal strains of H. pylori ameliorates glucose homeostasis in mice through a PPAR gamma-dependent mechanism and modulates macrophage and Treg cell infiltration into the abdominal white adipose tissue.
机构:
Univ Paris 06, Fac Med St Antoine, INSERM, U680, F-75012 Paris, France
Hop Tenon, AP HP, Serv Biochim & Hormonol, F-75970 Paris, FranceUniv Paris 06, Fac Med St Antoine, INSERM, U680, F-75012 Paris, France
Antuna-Puente, B.
;
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Feve, B.
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Fellahi, S.
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h-index: 0
机构:
Hop Tenon, AP HP, Serv Biochim & Hormonol, F-75970 Paris, FranceUniv Paris 06, Fac Med St Antoine, INSERM, U680, F-75012 Paris, France
Fellahi, S.
;
Bastard, J. -P.
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机构:
Univ Paris 06, Fac Med St Antoine, INSERM, U680, F-75012 Paris, France
Hop Tenon, AP HP, Serv Biochim & Hormonol, F-75970 Paris, FranceUniv Paris 06, Fac Med St Antoine, INSERM, U680, F-75012 Paris, France
机构:
Univ Nottingham, Nottingham Digest Dis Ctr, Biomed Res Unit, Queens Med Ctr, Nottingham NG7 2UH, England
Univ Nottingham, Inst Infect Immun & Inflammat, Ctr Biomol Sci, Nottingham NG7 2UH, EnglandUniv Nottingham, Nottingham Digest Dis Ctr, Biomed Res Unit, Queens Med Ctr, Nottingham NG7 2UH, England
Atherton, John C.
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Blaser, Martin J.
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机构:
NYU, Dept Med, Langone Med Ctr, New York, NY 10016 USA
NYU, Dept Microbiol, Langone Med Ctr, New York, NY 10016 USAUniv Nottingham, Nottingham Digest Dis Ctr, Biomed Res Unit, Queens Med Ctr, Nottingham NG7 2UH, England
机构:
Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, JapanFukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Azuma, T
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Suto, H
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机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Suto, H
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Ito, Y
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机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Ito, Y
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Ohtani, M
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机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Ohtani, M
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Dojo, M
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机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Dojo, M
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Kuriyama, M
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机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Kuriyama, M
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Kato, T
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机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
机构:
Univ Paris 06, Fac Med St Antoine, INSERM, U680, F-75012 Paris, France
Hop Tenon, AP HP, Serv Biochim & Hormonol, F-75970 Paris, FranceUniv Paris 06, Fac Med St Antoine, INSERM, U680, F-75012 Paris, France
Antuna-Puente, B.
;
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Feve, B.
;
Fellahi, S.
论文数: 0引用数: 0
h-index: 0
机构:
Hop Tenon, AP HP, Serv Biochim & Hormonol, F-75970 Paris, FranceUniv Paris 06, Fac Med St Antoine, INSERM, U680, F-75012 Paris, France
Fellahi, S.
;
Bastard, J. -P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, Fac Med St Antoine, INSERM, U680, F-75012 Paris, France
Hop Tenon, AP HP, Serv Biochim & Hormonol, F-75970 Paris, FranceUniv Paris 06, Fac Med St Antoine, INSERM, U680, F-75012 Paris, France
机构:
Univ Nottingham, Nottingham Digest Dis Ctr, Biomed Res Unit, Queens Med Ctr, Nottingham NG7 2UH, England
Univ Nottingham, Inst Infect Immun & Inflammat, Ctr Biomol Sci, Nottingham NG7 2UH, EnglandUniv Nottingham, Nottingham Digest Dis Ctr, Biomed Res Unit, Queens Med Ctr, Nottingham NG7 2UH, England
Atherton, John C.
;
Blaser, Martin J.
论文数: 0引用数: 0
h-index: 0
机构:
NYU, Dept Med, Langone Med Ctr, New York, NY 10016 USA
NYU, Dept Microbiol, Langone Med Ctr, New York, NY 10016 USAUniv Nottingham, Nottingham Digest Dis Ctr, Biomed Res Unit, Queens Med Ctr, Nottingham NG7 2UH, England
机构:
Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, JapanFukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Azuma, T
;
Suto, H
论文数: 0引用数: 0
h-index: 0
机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Suto, H
;
Ito, Y
论文数: 0引用数: 0
h-index: 0
机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Ito, Y
;
Ohtani, M
论文数: 0引用数: 0
h-index: 0
机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Ohtani, M
;
Dojo, M
论文数: 0引用数: 0
h-index: 0
机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Dojo, M
;
Kuriyama, M
论文数: 0引用数: 0
h-index: 0
机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan
Kuriyama, M
;
Kato, T
论文数: 0引用数: 0
h-index: 0
机构:Fukui Med Univ, Fac Med, Dept Internal Med 2, Matsuoka, Fukui 9101193, Japan