Titanium tetrachloride and chiral aliphatic alcohol as a new Lewis acid assisted chiral Bronsted acid for the enantioselective protonation of silyl enol ether

被引：15

作者：

Nakashima, D ^{[1
]}

Yamamoto, H ^{[1
]}

机构：

[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA

来源：

SYNLETT | 2006年 / 01期

关键词：

protonations; asymmetric synthesis; alcohols; titanium;

D O I：

10.1055/s-2005-922782

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A complex of TiCl4 and a chiral alcohol serves as highly reactive Lewis acid assisted chiral Bronsted acid (chiral LBA) for the enantioselective protonation of silyl enol ethers. Interestingly, the enantioselectivity depends on the preparation conditions of chiral LBA.

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收藏

页码：150 / 152

页数：3

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