Isolation of Antithrombotic Phenolic Compounds from the Leaves of Crataegus pinnatifida

被引：26

作者：

Song, Shao-Jiang ^{[2
,3
,4
]}

Li, Ling-Zhi ^{[2
,3
,4
]}

Gao, Pin-Yi ^{[5
]}

Yuan, Yan-Qiang ^{[6
]}

Wang, Ru-Ping ^{[2
,3
,4
]}

Liu, Ke-Chun ^{[6
]}

Peng, Ying ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Liaoning, Peoples R China

[3] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[4] Peking Union Med Coll, Beijing 100021, Peoples R China

[5] Shenyang Univ Chem Technol, Coll Chem Engn, Shenyang, Peoples R China

[6] Shandong Acad Sci, Inst Biol, Jinan, Peoples R China

来源：

PLANTA MEDICA | 2012年 / 78卷 / 18期

关键词：

Crataegus pinnatifida; Rosaceae; phenolic compounds; antithrombotic activity; GENETIC MODEL; FRUIT;

D O I：

10.1055/s-0032-1327877

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Four novel phenolic compounds (1-4) were isolated from the leaves of Crataegus pinnatifida, along with three known ones (5-7). Their structures were elucidated as: methyl 4-O-beta-D-glucopyranosyl-3-[(2E,6E)-8-O-beta-D-glucopyranosyl-3,7-dimethyl-2,6-octadienyl] benzoate (1), biphenyl-5-ol-3-O-beta-D-glucoside (2), 3,4'-dimethoxy-biphenyl-5-ol-4-O-beta-D-glucoside (3), (E)-6-(benzoyloxy)-1-hydroxyhex-3-en-2-O-beta-D-glucoside (4), shanyenoside A (5), eriodectyol (6), and 2 ''-O-rhamnosyl vitexin (7), using a combination of mass spectroscopy, 1D and 2D NMR spectroscopy, and chemical analysis. The antithrombotic activity of the isolated compounds was investigated on the transgenic zebra fish system. Among them, eriodectyol (6) potently inhibited the production of thrombus.

引用

页码：1967 / 1971

页数：5

共 20 条

[1]

NMR-SPECTROSCOPY IN THE STRUCTURAL ELUCIDATION OF OLIGOSACCHARIDES AND GLYCOSIDES [J].