Monoclonal antibodies in excess: A simple way to avoid immunogenicity in patients?

被引：24

作者：

Chaigne, Benjamin ^{[1
,2
]}

Watier, Herve ^{[1
,2
,3
,4
]}

机构：

[1] CHRU Tours, Lab Immunol, Tours, France

[2] Univ Tours, Tours, France

[3] UMR 7292, Tours, France

[4] CNRS, UMR 7292, Tours, France

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2015年 / 136卷 / 03期

关键词：

INFLIXIMAB; PHARMACOKINETICS; DISEASE;

D O I：

10.1016/j.jaci.2015.03.013

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

[No abstract available]

引用

收藏

页码：814 / +

页数：3

相关论文

共 7 条

[1]

Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease [J].

Baert, F ;

Noman, M ;

Vermeire, S ;

Van Assche, G ;

D'Haens, G ;

Carbonez, A ;

Rutgeerts, P .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (07) :601-608

[2]

Individualized monitoring of drug bioavailability and immunogenicity in rheumatoid arthritis patients treated with the tumor necrosis factor α inhibitor infliximab [J].

Bendtzen, Klaus ;

Geborek, Pierre ;

Svenson, Morten ;

Larsson, Lotta ;

Kapetanovic, Meliha C. ;

Saxne, Tore .

ARTHRITIS AND RHEUMATISM, 2006, 54 (12) :3782-3789

[3]

Pharmacokinetics, Pharmacodynamics and Physiologically-Based Pharmacokinetic Modelling of Monoclonal Antibodies [J].

Dostalek, Miroslav ;

Gardner, Iain ;

Gurbaxani, Brian M. ;

Rose, Rachel H. ;

Chetty, Manoranjenni .

CLINICAL PHARMACOKINETICS, 2013, 52 (02) :83-124

[4]

Antibodies toward infliximab are associated with low infliximab concentration at treatment initiation and poor infliximab maintenance in rheumatic diseases [J].

Ducourau, Emilie ;

Mulleman, Denis ;

Paintaud, Gilles ;

Lin, Delphine Chu Miow ;

Lauferon, Francine ;

Ternant, David ;

Watier, Herve ;

Goupille, Philippe .

ARTHRITIS RESEARCH & THERAPY, 2011, 13 (03)

[5]

THE INTERNAL IMAGE-LIKE ANTIIDIOTYPIC RESPONSE TO A CD3-SPECIFIC MONOCLONAL-ANTIBODY IN PRIMATES IS DEPENDENT ON THE T-CELL-BINDING PROPERTIES OF THE INJECTED ANTIBODY [J].

JONKER, M ;

NOOIJ, FJM .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1987, 17 (10) :1519-1522

[6]

A Novel Strategy To Reduce the Immunogenicity of Biological Therapies [J].

Somerfield, Jennifer ;

Hill-Cawthorne, Grant A. ;

Lin, Andrew ;

Zandi, Michael S. ;

McCarthy, Claire ;

Jones, Joanne L. ;

Willcox, Michael ;

Shaw, David ;

Thompson, Sara A. J. ;

Compston, Alastair S. ;

Hale, Geoff ;

Waldmann, Herman ;

Coles, Alasdair J. .

JOURNAL OF IMMUNOLOGY, 2010, 185 (01) :763-768

[7]

Ternant D, 2008, THER DRUG MONIT, V30, P523, DOI 10.1097/FTD.0b013e318180e300