Unraveling the KNOTTED1 regulatory network in maize meristems

被引：230

作者：

Bolduc, Nathalie ^{[1
]}

Yilmaz, Alper ^{[2
]}

Mejia-Guerra, Maria Katherine ^{[2
]}

Morohashi, Kengo ^{[2
]}

O'Connor, Devin ^{[1
]}

Grotewold, Erich ^{[2
]}

Hake, Sarah ^{[1
]}

机构：

[1] Univ Calif Berkeley, Ctr Plant Gene Express, USDA, ARS,Plant & Microbial Biol Dept, Berkeley, CA 94720 USA

[2] Ohio State Univ, Dept Mol Genet, Ctr Appl Plant Sci, Columbus, OH 43210 USA

来源：

GENES & DEVELOPMENT | 2012年 / 26卷 / 15期

基金：

美国国家科学基金会;

关键词：

KNOX transcription factors; chromatin immunoprecipitation; gene regulation; maize; SHOOT APICAL MERISTEM; HOMEOBOX GENE; ARABIDOPSIS DEVELOPMENT; AUXIN TRANSPORT; EXPRESSION; TRANSCRIPTION; CYTOKININ; PROTEINS; MAINTENANCE; MUTATIONS;

D O I：

10.1101/gad.193433.112

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

KNOTTED1 (KN1)-like homeobox (KNOX) transcription factors function in plant meristems, self-renewing structures consisting of stem cells and their immediate daughters. We defined the KN1 cistrome in maize inflorescences and found that KN1 binds to several thousand loci, including 643 genes that are modulated in one or multiple tissues. These KN1 direct targets are strongly enriched for transcription factors (including other homeobox genes) and genes participating in hormonal pathways, most significantly auxin, demonstrating that KN1 plays a key role in orchestrating the upper levels of a hierarchical gene regulatory network that impacts plant meristem identity and function.

引用

页码：1685 / 1690

页数：6

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