Oxidative stress and inflammatory markers in normal pregnancy and preeclampsia

被引：75

作者：

Bernardi, Fabiana ^{[1
]}

Guolo, Francieli ^{[1
]}

Bortolin, Thaize ^{[1
]}

Petronilho, Fabricia ^{[1
]}

Dal-Pizzol, Felipe ^{[1
]}

机构：

[1] Univ Extremo Sul Catarinense, Lab Fisiopatol Expt, BR-88006000 Criciuma, SC, Brazil

来源：

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | 2008年 / 34卷 / 06期

关键词：

inflammation; oxidative stress; preeclampsia;

D O I：

10.1111/j.1447-0756.2008.00803.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Aim: Although previous investigators have demonstrated the presence of oxidative stress and inflammation in preeclampsia, none directly correlate both to preeclampsia. Methods: We determined in 35 preeclamptic and 35 normotensive pregnant women plasma levels of thiobarbituric acid reactive species, protein carbonyl, tumour necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), IL-6 and IL-10. Results: Plasma thiobarbituric acid reactive species and protein carbonyls were higher in preeclamptic patients. TNF-alpha and IL-6 (but not IL-1 beta or IL-10) were higher in preeclamptic patients. We found significant correlation between plasma IL-6 and carbonyls, and these correlated to blood pressure. Conclusions: We demonstrated that some oxidative and inflammatory mediators were altered in preeclampsia, and some correlated to blood pressure.

引用

页码：948 / 951

页数：4

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