Effects of calcium and vitamin D supplementation on blood pressure and serum lipids and carotenoids: a randomized, double-blind, placebo-controlled, clinical trial

被引:42
作者
Chai, Weiwen [1 ]
Cooney, Robert V. [2 ]
Franke, Adrian A. [3 ]
Bostick, Roberd M. [4 ,5 ]
机构
[1] Logan Univ, Dept Nutr Sci, Chesterfield, MO 63017 USA
[2] Univ Hawaii, Dept Publ Hlth Sci, Honolulu, HI 96822 USA
[3] Univ Hawaii, Ctr Canc, Nat Prod & Expt Therapeut Program, Honolulu, HI 96822 USA
[4] Emory Univ, Dept Epidemiol, Atlanta, GA 30322 USA
[5] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA
基金
美国国家卫生研究院;
关键词
Calcium; Vitamin D; Lipids; Blood pressure; Carotenoids; DIETARY CALCIUM; CARDIOVASCULAR-DISEASE; ORAL CALCIUM; LONG-TERM; CHOLESTEROL-METABOLISM; RISK-FACTORS; BEEF TALLOW; METAANALYSIS; RATS; MEN;
D O I
10.1016/j.annepidem.2013.07.003
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Purpose: To estimate the effects of calcium or vitamin D supplementation or a combination of both on blood pressure and serum lipid and carotenoid levels. Methods: Ninety-two colorectal adenoma patients were randomized in a pilot, double-blind, placebo-controlled clinical trial of supplemental vitamin D-3 800 IU and elemental calcium 2.0 g (as calcium carbonate) alone or in combination in divided doses twice daily with meals over 6 months. Results: Relative to placebo, mean serum triglycerides decreased 30% (P = .10) and 32% (P = .10) in the calcium and calcium plus vitamin D-3 treatment groups, respectively. When the two calcium intervention groups were pooled and compared with the pooled noncalcium groups, the estimated supplemental calcium treatment effects were statistically significant for triglycerides (P = .04). Similar but nonstatistically significant decreases (5%-7%) were observed for serum total cholesterol levels. Mean systolic blood pressure increased 6% (P = .08) in the calcium group; otherwise, there were no appreciable changes in systolic or diastolic blood pressures in any active treatment group. Mean serum total carotenoid levels decreased 14% (P = .07) in the calcium and 9% (P = .10) in the calcium plus vitamin D-3 groups. Conclusions: Our results suggest that supplemental calcium alone or combined with vitamin D-3 but not vitamin D-3 alone may reduce serum lipids and lipophilic micronutrients. (c) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:564 / 570
页数:7
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