Exosomes from human adipose-derived mesenchymal stem cells promote migration through Wnt signaling pathway in a breast cancer cell model

被引：346

作者：

Lin, Ruizhu ^{[1
,2
,3
]}

Wang, Shihua ^{[1
,2
,3
]}

Zhao, Robert Chunhua ^{[1
,2
,3
,4
]}

机构：

[1] Chinese Acad Med Sci, Ctr Excellence Tissue Engn, Inst Basic Med Sci, Beijing 100730, Peoples R China

[2] Chinese Acad Med Sci, Sch Basic Med, Beijing 100730, Peoples R China

[3] Peking Union Med Coll, Beijing 100021, Peoples R China

[4] Beijing Union Med Coll Hosp, Beijing, Peoples R China

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2013年 / 383卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

Exosome; Mesenchymal stem cell; MCF7; Wnt; Migration; METASTASIS;

D O I：

10.1007/s11010-013-1746-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Human mesenchymal stem cell (MSC)-conditioned medium (CM) was previously reported to affect the biology of tumor cells; however, the precise mechanisms remain unclear. Here, we show that MSCs secreted 40-100 nm particles, which have the typical characteristics of exosomes, and these MSC-derived exosomes promoted migration of the breast cancer cell line MCF7. Global gene expression profiling revealed that several cancer-related signaling pathways were upregulated after exosome treatment in MCF7, and the Wnt signaling pathway was further confirmed to be activated. Our findings demonstrated a new mechanism through which MSC-CM may contribute to tumor cell migration.

引用

页码：13 / 20

页数：8

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