Autophagy: Cancer's Friend or Foe?

被引：183

作者：

Bhutia, Sujit K. ^{[1
]}

Mukhopadhyay, Subhadip ^{[1
]}

Sinha, Niharika ^{[1
]}

Das, Durgesh Nandini ^{[1
]}

Panda, Prashanta Kumar ^{[1
]}

Patra, Samir K. ^{[1
]}

Maiti, Tapas K. ^{[2
]}

Mandal, Mahitosh ^{[3
]}

Dent, Paul ^{[4
,5
,6
]}

Wang, Xiang-Yang ^{[5
,6
,7
]}

Das, Swadesh K. ^{[5
,7
]}

Sarkar, Devanand ^{[5
,6
,7
]}

Fisher, Paul B. ^{[5
,6
,7
]}

机构：

[1] Natl Inst Technol Rourkela, Dept Life Sci, Rourkela, Odisha, India

[2] Indian Inst Technol, Dept Biotechnol, Kharagpur 721302, W Bengal, India

[3] Indian Inst Technol, Sch Med Sci & Technol, Kharagpur 721302, W Bengal, India

[4] Virginia Commonwealth Univ, Med Coll Virginia, Dept Neurosurg, Richmond, VA 23298 USA

[5] Virginia Commonwealth Univ, Sch Med, VCU Inst Mol Med, Richmond, VA USA

[6] Virginia Commonwealth Univ, Sch Med, VCU Massey Canc Ctr, Richmond, VA USA

[7] Virginia Commonwealth Univ, Sch Med, Dept Human & Mol Genet, Richmond, VA USA

来源：

ADVANCES IN CANCER RESEARCH, VOL 118 | 2013年 / 118卷

关键词：

ENDOPLASMIC-RETICULUM STRESS; CELL-DEATH; REGULATES AUTOPHAGY; PROTECTIVE AUTOPHAGY; TUMOR PROGRESSION; MEDIATED CLEAVAGE; PROSTATE-CANCER; APOPTOSIS; GENE; PATHWAY;

D O I：

10.1016/B978-0-12-407173-5.00003-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The functional relevance of autophagy in tumor formation and progression remains controversial. Autophagy can promote tumor suppression during cancer initiation and protect tumors during progression. Autophagy-associated cell death may act as a tumor suppressor, with several autophagy-related genes deleted in cancers. Loss of autophagy induces genomic instability and necrosis with inflammation in mouse tumor models. Conversely, autophagy enhances survival of tumor cells subjected to metabolic stress and may promote metastasis by enhancing tumor cell survival under environmental stress. Unraveling the complex molecular regulation and multiple diverse roles of autophagy is pivotal in guiding development of rational and novel cancer therapies.

引用

页码：61 / 95

页数：35

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