Antigenic structure of the hemagglutinin of H9N2 influenza viruses

被引：52

作者：

Okamatsu, Masatoshi ^{[1
,3
]}

Sakoda, Yoshihiro ^{[1
,3
]}

Kishida, Noriko ^{[1
,3
]}

Isoda, Norikazu ^{[1
,3
]}

Kida, Hiroshi ^{[2
,3
,4
]}

机构：

[1] Hokkaido Univ, Grad Sch Vet Med, Dept Dis Control, Microbiol Lab, Sapporo, Hokkaido 0600818, Japan

[2] Hokkaido Univ Res Ctr Zoonosis Control, N 21, W 11, Kita Ku, Sapporo, Hokkaido 0010021, Japan

[3] Hokkaido Univ, Grad Sch Vet Med, Dept Dis Control, Microbiol Lab,Kita Ku, Sapporo, Hokkaido 0600818, Japan

[4] Hokkaido Univ, Res Ctr Zoonosis Control, Sapporo, Hokkaido 0010021, Japan

来源：

ARCHIVES OF VIROLOGY | 2008年 / 153卷 / 12期

关键词：

D O I：

10.1007/s00705-008-0243-2

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The hemagglutinins (HAs) of H9 influenza viruses isolated from birds and mammals of different species were antigenically and genetically analyzed. Antigenic variants were selected from A/swine/Hong Kong/10/98 (H9N2) and A/duck/Hokkaido/13/00 (H9N2) in the presence of monoclonal antibodies (MAbs). Based on the reactivity patterns of these mutants with a panel of MAbs, at least five non-overlapping antigenic sites were defined using eight MAbs which recognized seven distinct epitopes on the H9 HA molecule. Based on the reactivity patterns with the panel of monoclonal antibodies, 21 H9N2 virus strains isolated from birds and mammals were divided into 7 antigenically distinct groups. The present findings indicate that it is important to monitor the antigenic variation in H9 influenza viruses. The panel of MAbs in the present study, thus, should be useful for detailed antigenic analysis of the H9 HAs for epidemiological studies, the selection of vaccine strains, and diagnosis.

引用

页码：2189 / 2195

页数：7

共 31 条

[1] Evaluation of pathogenic potential of avian influenza virus serotype H9N2 in chickens [J].