Nickel-induced plasma lipid peroxidation and effect of antioxidants in human blood:: Involvement hydroxyl radical formation and depletion of α-tocopherol

被引：25

作者：

Chen, CY ^{[1
]}

Su, YJ ^{[1
]}

Wu, PF ^{[1
]}

Shyu, MM ^{[1
]}

机构：

[1] Foo Yin Inst Technol, Dept Med Technol, Kaohsiung, Taiwan

来源：

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES | 2002年 / 65卷 / 12期

关键词：

D O I：

10.1080/00984100290071162

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

To provide evidence for the oxidative effect of nickel (Ni) treatment on blood, lipid peroxidation (LPO) and hydroxyl radical (.OH) generation were examined in human plasma. Nickel chloride induced LPO in plasma of human blood in vitro in a concentration-dependent (0-10 mM) and time-dependent (0-2 h) manner. The .OH production in plasma was quantified by measurement of conversion of salicylic acid (SA) into its hydroxylated products, 2,3- and 2,5-dihydroxybenzoate (DHB), The concentrations of 2,3- and 2,5-DHB in plasma increased in a concentration-dependent manner after Ni treatment for 1 h. Furthermore, a decreasing trend in alpha-tocopherol levels in plasma was observed after Ni treatment. Concurrent incubation with gluthathione (GSH), catechin (CTCH), and mannitol decreased lipid peroxidation and reduced .OH formation induced by Ni, but exacerbation of the decrease of alpha-tocopherol in plasma occurred with catechin.

引用

页码：843 / 852

页数：10

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