Cadherins and catenins: Role in signal transduction and tumor progression

被引：247

作者：

Behrens, J ^{[1
]}

机构：

[1] Max Delbruck Ctr Mol Med, Berlin, Germany

来源：

CANCER AND METASTASIS REVIEWS | 1999年 / 18卷 / 01期

关键词：

cell adhesion; wnt signaling; metastasis formation; cadherins; catenins;

D O I：

10.1023/A:1006200102166

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cadherins are transmembrane cell-cell adhesion molecules which are connected to the cytoskeleton by association with the cytoplasmic proteins, alpha-, beta-, and gamma-catenin (plakoglobin). beta-catenin has an additional role in the wnt signal transduction pathway in which it transmitts signals to the cell nucleus in complexes with transcription factors of the LEF-1/TCF family. The cell adhesion function of the epithelial E-cadherin is frequently disturbed in carcinomas either by downregulation or by mutation of the E-cadherin/catenin genes. The signaling function of beta-catenin is activated in tumors by mutations of beta-catenin or of the tumor suppressor gene product APC. In this review I will give an introduction to the structure and function of the cadherin/catenin complex and summarize findings which support a decisive role of these components in the development of cancer.

引用

页码：15 / 30

页数：16

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