Copy number variations in IL22 gene are associated with Psoriasis vulgaris

被引：30

作者：

Prans, Ele ^{[1
]}

Kingo, Kuelli ^{[2
,3
]}

Traks, Tanel ^{[1
,3
]}

Silm, Helgi ^{[3
]}

Vasar, Eero ^{[1
,2
]}

Koks, Sulev ^{[1
,2
]}

机构：

[1] Univ Tartu, Dept Physiol, EE-50090 Tartu, Estonia

[2] Univ Tartu, Ctr Translat Med, EE-50090 Tartu, Estonia

[3] Univ Tartu, Dept Dermatol & Venerol, EE-50090 Tartu, Estonia

来源：

HUMAN IMMUNOLOGY | 2013年 / 74卷 / 06期

关键词：

D O I：

10.1016/j.humimm.2013.01.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Psoriasis vulgaris (PsV) is a frequent, chronically relapsing, immune-mediated systemic disease with characteristic skin changes. IL22 is a cytokine of IL10 family, with significant proliferative effect on different cell lines. Copy number variations (CNV) have been discovered to have phenotypic consequences and are associated with various types of diseases. In the work presented here we analyzed the copy number variations in IL22 gene of exon1 and exon5. Our results showed that the IL22 gene exon1 was significantly associated with psoriasis severity (P < 0.0001). However, the association between IL22 gene exon5 copy numbers and psoriasis was not detected. (c) 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：792 / 795

页数：4

共 19 条

[1]

Genetics of psoriasis: The potential impact on new therapies [J].