Electrical stimulation prevents immobilization atrophy in skeletal muscle of rabbits

被引:80
作者
Qin, L [1 ]
Appell, HJ [1 ]
Chan, KM [1 ]
Maffulli, N [1 ]
机构
[1] GERMAN SPORTS UNIV COLOGNE,INST EXPT MORPHOL,COLOGNE,GERMANY
来源
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION | 1997年 / 78卷 / 05期
关键词
D O I
10.1016/S0003-9993(97)90166-0
中图分类号
R49 [康复医学];
学科分类号
100215 ;
摘要
Objective: To investigate the effect of unilateral cast immobilization with and without surface electrical stimulation (ES) on the tibialis anterior (TA) muscle of rabbits. Design: Prospective randomized trial, Setting: University medical school, Animals: 53 New Zealand White rabbits (aged 54 to 63 days, weight 1.73 to 1.91 kg), Methods and Intervention: Random assignment, for a 3-week period, to one of four groups: C group (control group), I group (immobilization group), S group (group of electrical stimulation which was stimulated isometrically at 50Hz, 30 minutes per day, 5 times a week), and IS group (immobilization group which, like the S-group, received electrical stimulation). Outcome Measures: Muscle wet weight, muscle fiber cross-sectional area, muscle fiber types, and muscle capillary supply. Results: Muscle wet weight decreased significantly in the I group by 19% (p less than or equal to .05), with a corresponding significant reduction in the total muscle fiber cross-sectional area of 26% (p less than or equal to .05). No significant changes were observed in muscle wet weight and muscle fiber cross-sectional area in the S and IS groups. Interstitial fibrosis was observed in the I group and occasionally in the IS group. No significant changes in the total number of muscle fiber types I and II were found in all experimental groups. The capillary supply of the S and IS groups did not change significantly. However, capillary-to-fiber ratio was significantly reduced by 20% with a simultaneously nonsignificant increase in capillary density (capillaries/mm(2)) of 11% (p > .05) in the I group. Furthermore, muscle fiber regeneration was observed predominantly in the I group, Conclusions: In this experimental model, ES effectively prevented immobilization-induced muscle atrophy by minimizing reduction of muscle fiber cross-sectional area,interstitial fibrosis, and impaired blood supply. (C) 1997 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation.
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页码:512 / 517
页数:6
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