Role of the second immunoglobulin-like loop of nectin in cell-cell adhesion

被引：44

作者：

Momose, Y ^{[1
]}

Honda, T ^{[1
]}

Inagaki, M ^{[1
]}

Shimizu, K ^{[1
]}

Irie, K ^{[1
]}

Nakanishi, H ^{[1
]}

Takai, Y ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Fac Med, Dept Mol Biol & Biochem, Suita, Osaka 5650871, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2002年 / 293卷 / 01期

关键词：

mectin; Ig-like cell adhesion molecule; cis-dimers; trans-dimers; cell-cell adhesions; adherens junctions;

D O I：

10.1016/S0006-291X(02)00183-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nectin is a Ca2+-independent immunoglobulin (Ig)-like cell-cell adhesion molecule that forms cell-cell adherens junctions cooperatively with E-cadherin in a variety of cells. Nectin has one transmembrane segment and three Ig-like loops in the extracellular region. The first Ig-like loop is essential for the trans-dimer formation of nectin of two neighboring cells, causing cell-cell adhesion. We show here that the second Ig-like loop is essential for the cis-dimer formation of nectin on the same cell, and that the cis-dimer formation is essential for the trans-dimer formation. (C) 2002 Elsevier Science (USA). All rights reserved.

引用

页码：45 / 49

页数：5

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