Genealogical trees, coalescent theory and the analysis of genetic polymorphisms

被引：440

作者：

Rosenberg, NA ^{[1
]}

Nordborg, M ^{[1
]}

机构：

[1] Univ So Calif, Program Mol & Computat Biol, Los Angeles, CA 90089 USA

来源：

NATURE REVIEWS GENETICS | 2002年 / 3卷 / 05期

关键词：

D O I：

10.1038/nrg795

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Improvements in genotyping technologies have led to the increased use of genetic polymorphism for inference about population phenomena, such as migration and selection. Such inference presents a challenge, because polymorphism data reflect a unique, complex, non-repeatable evolutionary history. Traditional analysis methods do not take this into account. A stochastic process known as the 'coalescent' presents a coherent statistical framework for analysis of genetic polymorphisms.

引用

页码：380 / 390

页数：11

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