Radiation necrosis of the brain in melanoma patients successfully treated with ipilimumab, three case studies

被引：46

作者：

Du Four, Stephanie ^{[1
,2
]}

Wilgenhof, Sofie ^{[1
]}

Duerinck, Johnny ^{[2
]}

Michotte, Alex ^{[3
]}

Van Binst, Anne ^{[4
]}

De Ridder, Mark ^{[5
]}

Neyns, Bart ^{[1
]}

机构：

[1] Univ Ziekenhuis Brussel, Dept Med Oncol, B-1090 Brussels, Belgium

[2] Univ Ziekenhuis Brussel, Dept Neurosurg, B-1090 Brussels, Belgium

[3] Univ Ziekenhuis Brussel, Dept Neuropathol, B-1090 Brussels, Belgium

[4] Univ Ziekenhuis Brussel, Dept Radiol, B-1090 Brussels, Belgium

[5] Univ Ziekenhuis Brussel, Dept Radiotherapy, B-1090 Brussels, Belgium

来源：

EUROPEAN JOURNAL OF CANCER | 2012年 / 48卷 / 16期

关键词：

Melanoma; Brain metastasis; Ipilimumab; Radiation necrosis; STEREOTACTIC RADIOSURGERY; METASTASES; TEMOZOLOMIDE; RADIOTHERAPY; DACARBAZINE;

D O I：

10.1016/j.ejca.2012.05.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Metastasis to the brain is a frequent event in patients with advanced melanoma. Despite treatment with neurosurgery, pancranial irradiation and high-precision conformal radiotherapy, the prognosis of patients suffering from melanoma brain metastasis has remained very poor. Ipilimumab is a new effective immunotherapy for the treatment of advanced melanoma and has demonstrated activity against brain metastases. We report three patients successfully treated with ipilimumab who subsequently developed focal necrosis of the brain following prior radiotherapy of their melanoma brain metastases. As new active systemic treatment options become available that improve the survival of patients with melanoma brain metastases, adequate diagnosis and management of the late sequela from radiation to the brain is likely to gain importance in the management of these patients. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：3045 / 3051

页数：7

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