Tertiary lymphoid organs in infection and autoimmunity

被引：307

作者：

Neyt, Katrijn ^{[1
,2
]}

Perros, Frederic ^{[3
]}

GeurtsvanKessel, Corine H. ^{[4
,5
]}

Hammad, Hamida ^{[1
,2
]}

Lambrecht, Bart N. ^{[1
,2
,5
]}

机构：

[1] VIB, Dept Mol Biomed Res, Lab Immunoregulat & Mucosal Immunol, Ghent, Belgium

[2] Univ Ghent, Lab Immunoregulat & Mucosal Immunol, Ghent, Belgium

[3] INSERM, U999, F-92350 Le Plessis Robinson, France

[4] Erasmus MC, Dept Virol, Rotterdam, Netherlands

[5] Erasmus MC, Dept Pulm Med, Rotterdam, Netherlands

来源：

TRENDS IN IMMUNOLOGY | 2012年 / 33卷 / 06期

关键词：

LYMPHOTOXIN-BETA-RECEPTOR; NONOBESE DIABETIC MICE; PROGRESSIVE MULTIPLE-SCLEROSIS; FIBROBLASTIC RETICULAR CELLS; TUMOR-NECROSIS-FACTOR; TISSUE-INDUCER CELLS; NAIVE T-CELLS; DENDRITIC CELLS; RHEUMATOID-ARTHRITIS; CHRONIC INFLAMMATION;

D O I：

10.1016/j.it.2012.04.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The lymph nodes (LNs) and spleen have an optimal structure that allows the interaction between T cells, B cells and antigen-presenting dendritic cells (DCs) on a matrix made up by stromal cells. Such a highly organized structure can also be formed in tertiary lymphoid organs (TLOs) at sites of infection or chronic immune stimulation. This review focuses on the molecular mechanisms of TLO formation and maintenance, the controversies surrounding the nature of the inducing events, and the functions of these structures in infection, transplantation and autoimmunity.

引用

页码：297 / 305

页数：9

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