Unlocking family secrets:: K+ channel transmembrane domains

被引:12
作者
Clapham, DE [1 ]
机构
[1] Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA
[2] Childrens Hosp, Boston, MA 02115 USA
关键词
D O I
10.1016/S0092-8674(00)80765-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:547 / 550
页数:4
相关论文
共 21 条
[1]   Mechanisms of disease - Ion channels - Basic science and clinical disease [J].
Ackerman, MJ ;
Clapham, DE .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (22) :1575-1586
[2]   Crystal structure and functional analysis of the HERG potassium channel N terminus: A eukaryotic PAS domain [J].
Cabral, JHM ;
Lee, A ;
Cohen, SL ;
Chait, BT ;
Li, M ;
Mackinnon, R .
CELL, 1998, 95 (05) :649-655
[3]   Structural implications of fluorescence quenching in the Shaker K+ channel [J].
Cha, A ;
Bezanilla, F .
JOURNAL OF GENERAL PHYSIOLOGY, 1998, 112 (04) :391-408
[4]   Structure of the MscL homolog from Mycobacterium tuberculosis:: A gated mechanosensitive ion channel [J].
Chang, G ;
Spencer, RH ;
Lee, AT ;
Barclay, MT ;
Rees, DC .
SCIENCE, 1998, 282 (5397) :2220-2226
[5]   Three distinct structural environments of a transmembrane domain in the inwardly rectifying potassium channel ROMK1 defined by perturbation [J].
Choe, S ;
Stevens, CF ;
Sullivan, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (26) :12046-12049
[6]   The structure of the potassium channel:: Molecular basis of K+ conduction and selectivity [J].
Doyle, DA ;
Cabral, JM ;
Pfuetzner, RA ;
Kuo, AL ;
Gulbis, JM ;
Cohen, SL ;
Chait, BT ;
MacKinnon, R .
SCIENCE, 1998, 280 (5360) :69-77
[7]   Crystal structures of a complexed and peptide-free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ [J].
Doyle, DA ;
Lee, A ;
Lewis, J ;
Kim, E ;
Sheng, M ;
MacKinnon, R .
CELL, 1996, 85 (07) :1067-1076
[8]  
Hille B., 1992, IONIC CHANNELS EXCIT
[9]   The activation gate of a voltage-gated K+ channel can be trapped in the open state by an intersubunit metal bridge [J].
Holmgren, M ;
Shin, KS ;
Yellen, G .
NEURON, 1998, 21 (03) :617-621
[10]   Crystal structure of the tetramerization domain of the Shaker potassium channel [J].
Kreusch, A ;
Pfaffinger, PJ ;
Stevens, CF ;
Choe, S .
NATURE, 1998, 392 (6679) :945-948